Alzheimer’s disease could appear as a result of an infection with a very common virus

La maladie d'Alzheimer peut-elle être déclenchée suite à une infection virale ? © Rasi, Abode Stock

Researchers from Tufts University in the United States present recent findings that support the hypothesis that Alzheimer’s disease may be triggered by a virus.

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[EN VIDÉO] What are the differences between bacteria and viruses?
They are microbes. They are very small and get confused quite easily. However, bacteria and viruses are two very different things. And in order to effectively fight against those who cause disease, it is best to clearly identify them.

Nearly 225,000 people in France declare Alzheimer’s disease every year, most of them after the age of 65. Although this form of dementia is common, its origin is still hotly debated among specialists. There are, however, points of consensus: the Summary of … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/c/2/1/c21d283fdf_50038231_plaques-senile-amiloide- nephron -wiki-cc-30.jpg “data-url =” https://news.google.com/sante/definitions/biology-plaque-amyloid-11751/ “data-more =” Read more “>amyloid plaques and the aggregates of tau protein in the structure of neurons
Each neuron is made up of:
a cell body or perikaryon containing the nucleus; many dendritic ramifications (hence … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/4 / 8/4 / 4845b46c32_50034180_neuron- dr.jpg “data-url = “https://news.google.com/sante/definitions/biology-neuron-209/” data-more = “Read more”>neurons are involved in the occurrence of symptoms typical of Alzheimer’s diseaseand theinflammation which takes over the function of the brain
Located in the skull, the brain is the seat of higher functions (cognitive functions, senses, nerve responses) and vegetative functions. It is therefore an essential organ that regulates everything … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/5/c/b/5cb474dd85_121782_cerveau-3d .jpg “data- url = “https://news.google.com/health/definitions/biology-brain-3125/” data-more = “Read more”>brain This toxicity also depends on the dose of xenobiotic needed to … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/a/c/9/ac93ff44a1_50035323_symbole-toxic-yves- guillo -public-domain.jpg “data-url =” https://news.google.com/sante/definitions/medecine-toxicite-6517/ “data-more =” Read more “>toxicity.

To explain these observations, several hypotheses are proposed by scientists. Factors genetic seem to play an important role in the more frequent sporadic cases of Alzheimer’s, but a deregulation of amyloid protein synthesis or the intervention of a microorganism – a virus more often than not – it could also have an implication.

Experiences in vitro on cultured neurons

A team from Tufts University in the United States presents findings that fall within the framework of the “viral hypothesis” on the origin of Alzheimer’s disease. The latter establishes that a dormant virus in the brain – most often herpes virus 1 or HSV-1 – is “awakened” by as yet undefined factors and induces the symptoms of Alzheimer’s disease. ” Our findings suggest a path leading to Alzheimer’s disease, caused by infection with the characteristics of the Varicella Zoster virus.
Like all viruses of the Herpesviridae family and more precisely of the Varicellovirus genus, the … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/7/9/7/ 79777c7579_50035994_vzv – wiki.jpg “data-url =” https://news.google.com/health/definitions/medicine-virus-varicella-shingles-7948/ “data-more =” Read more “>VZV which triggers inflammation by waking the HSV-1 virus in the brain
explains the functions of Dana Cairn
Cairns are used to mark paths in arid, rocky areas or on glaciers. They can … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/5/c/3/5c360d42ac_50038920_cairn-summit-bugmonkey-flickr.jpg “data-url =” https : //news.google.com/sciences/definitions/homme-cairn-12817/ “data-more =” Read more “>Cairnsfirst author ofstudy published in Alzheimer’s disease journal.

To corroborate this hypothesis, they infected human neural stem cells with the two viruses and looked for the presence of specific Alzheimer’s markers: amyloid plaques and Tau aggregates, gliosis (proliferation of glial cells in the brain) and neuroinflammation. Their results show that the VZV virus alone does not cause the formation of amyloid plaques and Tau aggregates, such as HSV-1, but neuroinflammation and gliosis. This suggests, according to the scientists, an indirect action of the VZV virus. Furthermore, they observed that the infection of cells, in which HSV-1 is dormant, by the VZV virus reactivates the latter and causes changes typical of Alzheimer’s. ” It’s a double punch of two viruses that are very common and generally harmless, but laboratory studies suggest that if further exposure to VZV awakens dormant HSV-1, it could cause problems. “Says Dana Cairns.

These experiments alone are not robust enough to confirm a causal link between Alzheimer’s disease and the VZV and HSV-1 viruses, although the observations point in this direction. Furthermore, the different hypotheses being studied on the origin of Alzheimer’s disease are not necessarily mutually exclusive. Viral infection could be a factor to consider in Alzheimer’s disease, among others.

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